Molecular Details
DICL_CP_0379300
- (3-chlorophenyl)-[4-[(4-methoxyphenoxy)methyl]-1-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]metha
Basic Molecular Information
Basic Information
DICL ID
DICL_CP_0379300
PubChem CID
Molecular Formula
C22H22ClN3O3 Molecular Weight
411.889 g/mol
Synonyms/Alias
[CHEMBL4644857; SCHEMBL24049343; BDBM50545711]
InChI Key
IPXDISVBOWEWKA-UHFFFAOYSA-N
InChI
InChI=1S/C22H22ClN3O3/c1-25-20-10-11-26(22(27)15-4-3-5-16(23)12-15)21(19(20)13-24-25)14-29-18-8-6-17...
IUPAC Name
(3-chlorophenyl)-[4-[(4-methoxyphenoxy)methyl]-1-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]metha
CAS Number
N/A (Not available)
Structure Information
Chemical Structure Visualization
SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF
29 32 0 0 0 0 0 0 0 0999 V2000
5.0580 -4.5068 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.6188 -4.0839 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
3.1151 -2...
Experimental Data
Activity Data
Target Ion Channel
Glutamate receptor ionotropic subunit NMDA 1/2D
Uniprot Accession Number
Function
Positive Allosteric Modulator
Species
Mus musculus (Mouse)
IC50
N/A (Not available)
EC50
EC50: >31623 nM
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)
Experimental Conditions
pH
pH 7.4
Holding Potential
40 mV mV
Temperature
23 °C
Test Method
Patch-clamping
Test Species
Xenopus laevis oocyte
Binding Information
Binding Site
Extracellular domain
Binding Site Residue
Not specified
Disease Information
Related Disease
Not specified
References
Computed Properties
Heavy Atom Count
29
Rotatable Bonds
5
logP
3.9007
Complexity
110.6305
TPSA (Ų)
56.59
H-Bond Donors
0
H-Bond Acceptors
5
Ring Count
4